Improving the solubility of nevirapine using a hydrotropy and mixed hydrotropy based solid dispersion approach
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چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drug Zaltoprofen by Mixed Hydrotropy Approach
In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers s...
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15 صفحه اولSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
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ژورنال
عنوان ژورنال: Polymers in Medicine
سال: 2017
ISSN: 0370-0747,2451-2699
DOI: 10.17219/pim/77093